5MQF

Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)

Summary for 5MQF

Entry DOI	10.2210/pdb5mqf/pdb
EMDB information	3545
Descriptor	Pre-mRNA-processing-splicing factor 8, Pre-mRNA-splicing factor SYF1, Pre-mRNA-splicing factor SYF2, ... (35 entities in total)
Functional Keywords	spliceosome, pre-mrna splicing, macromolecular complex, splicing
Biological source	Homo sapiens (Human) More
Total number of polymer chains	46
Total formula weight	2666327.59
Authors	Bertram, K.,Hartmuth, K.,Kastner, B. (deposition date: 2016-12-20, release date: 2017-03-22, Last modification date: 2018-11-21)
Primary citation	Bertram, K.,Agafonov, D.E.,Liu, W.T.,Dybkov, O.,Will, C.L.,Hartmuth, K.,Urlaub, H.,Kastner, B.,Stark, H.,Lu Hrmann, R. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature, 542:318-323, 2017 Cited by PubMed: 28076346 DOI: 10.1038/nature21079 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.9 Å)

Structure validation