5MNJ
Structure of MDM2-MDMX-UbcH5B-ubiquitin complex
Summary for 5MNJ
Entry DOI | 10.2210/pdb5mnj/pdb |
Descriptor | Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, E3 ubiquitin-protein ligase Mdm2, ... (7 entities in total) |
Functional Keywords | ubiquitin ligase, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 86014.67 |
Authors | Klejnot, M.,Huang, D.T. (deposition date: 2016-12-13, release date: 2017-05-31, Last modification date: 2024-01-17) |
Primary citation | Nomura, K.,Klejnot, M.,Kowalczyk, D.,Hock, A.K.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T. Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat. Struct. Mol. Biol., 24:578-587, 2017 Cited by PubMed: 28553961DOI: 10.1038/nsmb.3414 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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