5MF0
Crystal structure of Smad4-MH1 bound to the GGCCG site.
Summary for 5MF0
Entry DOI | 10.2210/pdb5mf0/pdb |
Descriptor | MH1 domain of human Smad4, DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP*CP*GP*T)-3'), ZINC ION, ... (5 entities in total) |
Functional Keywords | smads, transcription factor, dna complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : Q13485 |
Total number of polymer chains | 4 |
Total formula weight | 40479.19 |
Authors | Kaczmarska, Z.,Freier, R.,Marquez, J.A.,Macias, M.J. (deposition date: 2016-11-16, release date: 2017-11-15, Last modification date: 2024-01-17) |
Primary citation | Martin-Malpartida, P.,Batet, M.,Kaczmarska, Z.,Freier, R.,Gomes, T.,Aragon, E.,Zou, Y.,Wang, Q.,Xi, Q.,Ruiz, L.,Vea, A.,Marquez, J.A.,Massague, J.,Macias, M.J. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8:2070-2070, 2017 Cited by PubMed: 29234012DOI: 10.1038/s41467-017-02054-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.03 Å) |
Structure validation
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