5M8S

Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with phenylthiourea (PTU)

Summary for 5M8S

• Entry DOI: 10.2210/pdb5m8s/pdb
• Descriptor: 5,6-dihydroxyindole-2-carboxylic acid oxidase, N-PHENYLTHIOUREA, ZINC ION, ... (12 entities in total)
• Functional Keywords: human tyrosinase related protein 1, melanin biosynthesis, tyrosinase, oxidoreductase, unknown function
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 212927.16

Authors

Lai, X.,Soler-Lopez, M.,Wichers, H.J.,Dijkstra, B.W. (deposition date: 2016-10-29, release date: 2018-01-31, Last modification date: 2020-07-29)

• Primary citation: Lai, X.,Wichers, H.J.,Soler-Lopez, M.,Dijkstra, B.W.; Phenylthiourea Binding to Human Tyrosinase-Related Protein 1; Int J Mol Sci, 2020; DOI: 10.3390/ijms21030915

Experimental method

X-RAY DIFFRACTION (2.2 Å)