5M4U
ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)
Summary for 5M4U
Entry DOI | 10.2210/pdb5m4u/pdb |
Descriptor | Casein kinase II subunit alpha', 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, GLYCEROL, ... (7 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43942.09 |
Authors | Niefind, K.,Bischoff, N.,Yarmoluk, S.M.,Bdzhola, V.G.,Golub, A.G.,Balanda, A.O.,Prykhod'ko, A.O. (deposition date: 2016-10-19, release date: 2017-01-18, Last modification date: 2024-01-17) |
Primary citation | Niefind, K.,Bischoff, N.,Golub, A.G.,Bdzhola, V.G.,Balanda, A.O.,Prykhod'ko, A.O.,Yarmoluk, S.M. Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10:-, 2017 Cited by PubMed: 28085026DOI: 10.3390/ph10010009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.195 Å) |
Structure validation
Download full validation report