5M4I
Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under high-salt conditions
Summary for 5M4I
Entry DOI | 10.2210/pdb5m4i/pdb |
Descriptor | Casein kinase II subunit alpha, 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P68400 |
Total number of polymer chains | 1 |
Total formula weight | 40595.14 |
Authors | Niefind, K.,Bischoff, N.,Yarmoluk, S.M.,Bdzhola, V.G.,Golub, A.G.,Balanda, A.O.,Prykhod'ko, A.O. (deposition date: 2016-10-18, release date: 2017-01-18, Last modification date: 2024-01-17) |
Primary citation | Niefind, K.,Bischoff, N.,Golub, A.G.,Bdzhola, V.G.,Balanda, A.O.,Prykhod'ko, A.O.,Yarmoluk, S.M. Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10:-, 2017 Cited by PubMed: 28085026DOI: 10.3390/ph10010009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.218 Å) |
Structure validation
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