5M4I

Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under high-salt conditions

Summary for 5M4I

Entry DOI	10.2210/pdb5m4i/pdb
Descriptor	Casein kinase II subunit alpha, 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	protein kinase ck2, casein kinase 2, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P68400
Total number of polymer chains	1
Total formula weight	40595.14
Authors	Niefind, K.,Bischoff, N.,Yarmoluk, S.M.,Bdzhola, V.G.,Golub, A.G.,Balanda, A.O.,Prykhod'ko, A.O. (deposition date: 2016-10-18, release date: 2017-01-18, Last modification date: 2024-01-17)
Primary citation	Niefind, K.,Bischoff, N.,Golub, A.G.,Bdzhola, V.G.,Balanda, A.O.,Prykhod'ko, A.O.,Yarmoluk, S.M. Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10:-, 2017 Cited by PubMed: 28085026 DOI: 10.3390/ph10010009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.218 Å)

Structure validation