5M32
Human 26S proteasome in complex with Oprozomib
Summary for 5M32
Entry DOI | 10.2210/pdb5m32/pdb |
EMDB information | 4146 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (35 entities in total) |
Functional Keywords | proteasome, oprozomib, ups, drug-binding, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 47 |
Total formula weight | 1535198.08 |
Authors | Haselbach, D.,Schrader, J.,Lambrecht, F.,Henneberg, F.,Chari, A.,Stark, H. (deposition date: 2016-10-14, release date: 2017-07-05, Last modification date: 2019-12-11) |
Primary citation | Haselbach, D.,Schrader, J.,Lambrecht, F.,Henneberg, F.,Chari, A.,Stark, H. Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat Commun, 8:15578-15578, 2017 Cited by PubMed: 28541292DOI: 10.1038/ncomms15578 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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