5LIH

Structure of a peptide-substrate bound to PKCiota core kinase domain

Summary for 5LIH

Entry DOI	10.2210/pdb5lih/pdb
Descriptor	Protein kinase C iota type, PKC Epsilon pseudo substrate sequence, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
Functional Keywords	apkc, polarity, complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	86378.88
Authors	Soriano, E.V.,Purkiss, A.G.,McDonald, N.Q. (deposition date: 2016-07-14, release date: 2016-09-14, Last modification date: 2024-01-10)
Primary citation	Soriano, E.V.,Ivanova, M.E.,Fletcher, G.,Riou, P.,Knowles, P.P.,Barnouin, K.,Purkiss, A.,Kostelecky, B.,Saiu, P.,Linch, M.,Elbediwy, A.,Kjr, S.,O'Reilly, N.,Snijders, A.P.,Parker, P.J.,Thompson, B.J.,McDonald, N.Q. aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev.Cell, 38:384-398, 2016 Cited by PubMed: 27554858 DOI: 10.1016/j.devcel.2016.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation