5LIG

G-Quadruplex formed at the 5'-end of NHEIII_1 Element in human c-MYC promoter bound to triangulenium based fluorescence probe DAOTA-M2

Summary for 5LIG

• Entry DOI: 10.2210/pdb5lig/pdb
• NMR Information: BMRB: 34025
• Descriptor: DNA (5'-D(*TP*AP*GP*GP*GP*AP*GP*GP*GP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3'), 8,12-bis(2-morpholinoethyl)-8H-benzo[ij]xantheno[1,9,8-cdef][2,7]naphthyridin-12-iumhexafluorophosphate (2 entities in total)
• Functional Keywords: dna, g-quadruplex, c-myc promoter, ligand, daota-m2
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 7092.17

Authors

Kotar, A.,Wang, B.,Shivalingam, A.,Gonzalez-Garcia, J.,Vilar, R.,Plavec, J. (deposition date: 2016-07-14, release date: 2016-09-14, Last modification date: 2019-05-08)

• Primary citation: Kotar, A.,Wang, B.,Shivalingam, A.,Gonzalez-Garcia, J.,Vilar, R.,Plavec, J.; NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex.; Angew.Chem.Int.Ed.Engl., 55:12508-12511, 2016; PubMed: 27577037; DOI: 10.1002/anie.201606877

Experimental method

SOLUTION NMR