5LGY

Lysine 120-acetylated P53 DNA binding domain in a complex with the BAX response element.

Replaces:  5BUB

Summary for 5LGY

• Entry DOI: 10.2210/pdb5lgy/pdb
• Descriptor: Cellular tumor antigen p53, DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), ... (5 entities in total)
• Functional Keywords: transcription, acetylation, transcription factor, post-translational modification, tumor suppressor, dna binding specificity, apoptosis, induced fit, genetic code expansion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 102587.53

Authors

Arbely, E.,Vainer, R. (deposition date: 2016-07-08, release date: 2016-07-27, Last modification date: 2024-01-10)

• Primary citation: Vainer, R.,Cohen, S.,Shahar, A.,Zarivach, R.,Arbely, E.; Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode.; J.Mol.Biol., 428:3013-3025, 2016; PubMed: 27338200; DOI: 10.1016/j.jmb.2016.06.009

Experimental method

X-RAY DIFFRACTION (2.92 Å)