5LF4
Human 20S proteasome complex with Delanzomib at 2.0 Angstrom
Summary for 5LF4
Entry DOI | 10.2210/pdb5lf4/pdb |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (20 entities in total) |
Functional Keywords | proteasome, multicatalytic proteinase, ntn-hydrolase, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P25787 P49721 P28074 P20618 P28070 P28072 P25789 O14818 P28066 P25786 P25788 P60900 Q99436 P49720 |
Total number of polymer chains | 28 |
Total formula weight | 725177.53 |
Authors | Schrader, J.,Henneberg, F.,Mata, R.,Tittmann, K.,Schneider, T.R.,Stark, H.,Bourenkov, G.,Chari, A. (deposition date: 2016-06-30, release date: 2016-08-17, Last modification date: 2024-01-10) |
Primary citation | Schrader, J.,Henneberg, F.,Mata, R.A.,Tittmann, K.,Schneider, T.R.,Stark, H.,Bourenkov, G.,Chari, A. The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353:594-598, 2016 Cited by PubMed: 27493187DOI: 10.1126/science.aaf8993 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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