5LBQ
LSD1-CoREST1 in complex with quinazoline-derivative reversible inhibitor
Summary for 5LBQ
Entry DOI | 10.2210/pdb5lbq/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | oxidoreductase-repressor complex, lsd1, kdm1a, corest1, chromatin, epigenetic, oxidoreductase/repressor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O60341 Q9UKL0 |
Total number of polymer chains | 2 |
Total formula weight | 103310.10 |
Authors | Speranzini, V.,Rotili, D.,Ciossani, G.,Pilotto, S.,Forgione, M.,Lucidi, A.,Forneris, F.,Velankar, S.,Mai, A.,Mattevi, A. (deposition date: 2016-06-16, release date: 2016-09-21, Last modification date: 2024-01-10) |
Primary citation | Speranzini, V.,Rotili, D.,Ciossani, G.,Pilotto, S.,Marrocco, B.,Forgione, M.,Lucidi, A.,Forneris, F.,Mehdipour, P.,Velankar, S.,Mai, A.,Mattevi, A. Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features. Sci Adv, 2:e1601017-e1601017, 2016 Cited by PubMed: 27626075DOI: 10.1126/sciadv.1601017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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