5L3A
Fragment-based discovery of 6-arylindazole JAK inhibitors
Summary for 5L3A
Entry DOI | 10.2210/pdb5l3a/pdb |
Descriptor | Tyrosine-protein kinase JAK2, ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide (3 entities in total) |
Functional Keywords | double f mutant, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34741.77 |
Authors | Soerensen, M.D.,Dack, K.N.,Greve, D.R.,Ritzen, A. (deposition date: 2016-04-06, release date: 2016-04-27, Last modification date: 2024-05-08) |
Primary citation | Ritzen, A.,Srensen, M.D.,Dack, K.N.,Greve, D.R.,Jerre, A.,Carnerup, M.A.,Rytved, K.A.,Bagger-Bahnsen, J. Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors. Acs Med.Chem.Lett., 7:641-646, 2016 Cited by PubMed: 27326341DOI: 10.1021/acsmedchemlett.6b00087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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