5L3A

Fragment-based discovery of 6-arylindazole JAK inhibitors

Summary for 5L3A

Entry DOI	10.2210/pdb5l3a/pdb
Descriptor	Tyrosine-protein kinase JAK2, ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide (3 entities in total)
Functional Keywords	double f mutant, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34741.77
Authors	Soerensen, M.D.,Dack, K.N.,Greve, D.R.,Ritzen, A. (deposition date: 2016-04-06, release date: 2016-04-27, Last modification date: 2019-10-23)
Primary citation	Ritzen, A.,Srensen, M.D.,Dack, K.N.,Greve, D.R.,Jerre, A.,Carnerup, M.A.,Rytved, K.A.,Bagger-Bahnsen, J. Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors. Acs Med.Chem.Lett., 7:641-646, 2016 Cited by PubMed: 27326341 DOI: 10.1021/acsmedchemlett.6b00087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation