5L2Y
Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl] cyclobutane-1-carboxylic acid
Summary for 5L2Y
Entry DOI | 10.2210/pdb5l2y/pdb |
Descriptor | Coagulation factor VII (Heavy Chain), Coagulation factor VII (Light Chain), 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclobutane-1-carboxylic acid, ... (7 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35368.29 |
Authors | |
Primary citation | Ladziata, V.U.,Glunz, P.W.,Zou, Y.,Zhang, X.,Jiang, W.,Jacutin-Porte, S.,Cheney, D.L.,Wei, A.,Luettgen, J.M.,Harper, T.M.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S. Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 26:5051-5057, 2016 Cited by PubMed: 27612545DOI: 10.1016/j.bmcl.2016.08.088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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