5KVT
THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB
Summary for 5KVT
Entry DOI | 10.2210/pdb5kvt/pdb |
Descriptor | High affinity nerve growth factor receptor, Entrectinib, GLYCEROL, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase-transfer complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single- pass type I membrane protein : P04629 |
Total number of polymer chains | 1 |
Total formula weight | 34161.39 |
Authors | Jin, L.,Yan, S.,Wei, G.,Li, G.,Harris, J.,Vernier, J.-M. (deposition date: 2016-07-15, release date: 2017-12-27, Last modification date: 2023-10-04) |
Primary citation | Drilon, A. Antitumor Activity and Safety of the Pan-TRK, ROS1, and ALK inhibitor Entrectinib (RXDX-101): Combined Results from Two Phase I Trials To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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