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5KPM

Glycogen Synthase Kinase 3 beta Complexed with BRD3731

Summary for 5KPM
Entry DOI10.2210/pdb5kpm/pdb
Related5KPK 5KPL
DescriptorGlycogen synthase kinase-3 beta, (4~{S})-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one (3 entities in total)
Functional Keywordsprotein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P49841
Total number of polymer chains2
Total formula weight95114.01
Authors
Lakshminarasimhan, D.,White, A.,Nadupalli, A.,Suto, R.K. (deposition date: 2016-07-04, release date: 2018-03-14, Last modification date: 2018-03-21)
Primary citationWagner, F.F.,Benajiba, L.,Campbell, A.J.,Weiwer, M.,Sacher, J.R.,Gale, J.P.,Ross, L.,Puissant, A.,Alexe, G.,Conway, A.,Back, M.,Pikman, Y.,Galinsky, I.,DeAngelo, D.J.,Stone, R.M.,Kaya, T.,Shi, X.,Robers, M.B.,Machleidt, T.,Wilkinson, J.,Hermine, O.,Kung, A.,Stein, A.J.,Lakshminarasimhan, D.,Hemann, M.T.,Scolnick, E.,Zhang, Y.L.,Pan, J.Q.,Stegmaier, K.,Holson, E.B.
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Sci Transl Med, 10:-, 2018
Cited by
PubMed: 29515000
DOI: 10.1126/scitranslmed.aam8460
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.69 Å)
Structure validation

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