5KPL
Glycogen Synthase Kinase 3 beta Complexed with BRD0705
Summary for 5KPL
Entry DOI | 10.2210/pdb5kpl/pdb |
Related | 5KPK 5KPM |
Descriptor | Glycogen synthase kinase-3 beta, (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one (3 entities in total) |
Functional Keywords | protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P49841 |
Total number of polymer chains | 2 |
Total formula weight | 95001.80 |
Authors | Lakshminarasimhan, D.,White, A.,Nadupalli, A.,Suto, R.K. (deposition date: 2016-07-04, release date: 2018-03-14, Last modification date: 2018-03-21) |
Primary citation | Wagner, F.F.,Benajiba, L.,Campbell, A.J.,Weiwer, M.,Sacher, J.R.,Gale, J.P.,Ross, L.,Puissant, A.,Alexe, G.,Conway, A.,Back, M.,Pikman, Y.,Galinsky, I.,DeAngelo, D.J.,Stone, R.M.,Kaya, T.,Shi, X.,Robers, M.B.,Machleidt, T.,Wilkinson, J.,Hermine, O.,Kung, A.,Stein, A.J.,Lakshminarasimhan, D.,Hemann, M.T.,Scolnick, E.,Zhang, Y.L.,Pan, J.Q.,Stegmaier, K.,Holson, E.B. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10:-, 2018 Cited by PubMed: 29515000DOI: 10.1126/scitranslmed.aam8460 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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