5KHR
Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C)
Summary for 5KHR
Entry DOI | 10.2210/pdb5khr/pdb |
Related | 5KHU |
EMDB information | 4021 4025 |
Descriptor | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 13, Anaphase-promoting complex subunit 2, ... (16 entities in total) |
Functional Keywords | ubiquitination, cell cycle, protein complex, mitosis |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q9BS18 P30260 Q8NHZ8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q12834 Q13042 Cytoplasm : Q9NYG5 Q96DE5 |
Total number of polymer chains | 21 |
Total formula weight | 1231156.22 |
Authors | VanderLinden, R.,Yamaguchi, M.,Dube, P.,Haselbach, D.,Stark, H.,Schulman, B.A. (deposition date: 2016-06-15, release date: 2016-08-24, Last modification date: 2024-03-06) |
Primary citation | Yamaguchi, M.,VanderLinden, R.,Weissmann, F.,Qiao, R.,Dube, P.,Brown, N.G.,Haselbach, D.,Zhang, W.,Sidhu, S.S.,Peters, J.M.,Stark, H.,Schulman, B.A. Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63:593-607, 2016 Cited by PubMed: 27522463DOI: 10.1016/j.molcel.2016.07.003 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.1 Å) |
Structure validation
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