5KBQ

Pak1 in complex with bis-anilino pyrimidine inhibitor

Summary for 5KBQ

Entry DOI	10.2210/pdb5kbq/pdb
Descriptor	Serine/threonine-protein kinase PAK 1, [4-methyl-3-[methyl-[2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]pyrimidin-4-yl]amino]phenyl]methanol (3 entities in total)
Functional Keywords	serine/threonine-protein kinase pak1, kinase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q13153
Total number of polymer chains	2
Total formula weight	65148.28
Authors	Ferguson, A. (deposition date: 2016-06-03, release date: 2016-09-28, Last modification date: 2023-09-27)
Primary citation	McCoull, W.,Hennessy, E.J.,Blades, K.,Chuaqui, C.,Dowling, J.E.,Ferguson, A.D.,Goldberg, F.W.,Howe, N.,Jones, C.R.,Kemmitt, P.D.,Lamont, G.,Varnes, J.G.,Ward, R.A.,Yang, B. Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. ACS Med Chem Lett, 7:1118-1123, 2016 Cited by PubMed: 27994749 DOI: 10.1021/acsmedchemlett.6b00322 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation