5JXE
Human PD-1 ectodomain complexed with Pembrolizumab Fab
Summary for 5JXE
Entry DOI | 10.2210/pdb5jxe/pdb |
Descriptor | Programmed cell death protein 1, Pembrolizumab Fab light chain, Pembrolizumab Fab heavy chain, ... (4 entities in total) |
Functional Keywords | human pd-1 pembrolizumab fab, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: Q15116 |
Total number of polymer chains | 6 |
Total formula weight | 120328.11 |
Authors | Na, Z.,Bharath, S.R.,Song, H. (deposition date: 2016-05-13, release date: 2016-08-10, Last modification date: 2023-11-08) |
Primary citation | Na, Z.,Yeo, S.P.,Bharath, S.R.,Bowler, M.W.,Balijkcij, E.,Wang, C.I.,Song, H. Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab. Cell Res., 27:147-150, 2017 Cited by PubMed: 27325296DOI: 10.1038/cr.2016.77 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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