5JSN

Bcl2-inhibitor complex

Summary for 5JSN

• Entry DOI: 10.2210/pdb5jsn/pdb
• Related: 4OYD 5JSB
• Descriptor: Apoptosis regulator Bcl-2, Bcl2 inhibitor (3 entities in total)
• Functional Keywords: bcl-2, antibcl2, complex, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Mitochondrion outer membrane ; Single-pass membrane protein : P10415
• Total number of polymer chains: 4
• Total formula weight: 75575.60

Authors

Shen, B.W.,Stoddard, B.L. (deposition date: 2016-05-09, release date: 2016-11-16, Last modification date: 2024-03-06)

• Primary citation: Berger, S.,Procko, E.,Margineantu, D.,Lee, E.F.,Shen, B.W.,Zelter, A.,Silva, D.A.,Chawla, K.,Herold, M.J.,Garnier, J.M.,Johnson, R.,MacCoss, M.J.,Lessene, G.,Davis, T.N.,Stayton, P.S.,Stoddard, B.L.,Fairlie, W.D.,Hockenbery, D.M.,Baker, D.; Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.; Elife, 5:-, 2016; PubMed: 27805565; DOI: 10.7554/eLife.20352

Experimental method

X-RAY DIFFRACTION (2.1 Å)