5JRQ
BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM
Summary for 5JRQ
Entry DOI | 10.2210/pdb5jrq/pdb |
Related | 5JSM 5JT2 |
Descriptor | Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | kinase, dimer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65126.64 |
Authors | Grasso, M.J.,Marmorstein, R. (deposition date: 2016-05-06, release date: 2016-09-14, Last modification date: 2023-10-18) |
Primary citation | Grasso, M.,Estrada, M.A.,Ventocilla, C.,Samanta, M.,Maksimoska, J.,Villanueva, J.,Winkler, J.D.,Marmorstein, R. Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. Acs Chem.Biol., 11:2876-2888, 2016 Cited by PubMed: 27571413DOI: 10.1021/acschembio.6b00529 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.287 Å) |
Structure validation
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