5JFW
Crystal structure of TrkA in complex with PF-05247452
Summary for 5JFW
Entry DOI | 10.2210/pdb5jfw/pdb |
Related | 5JFS 5JFV 5JFX |
Descriptor | High affinity nerve growth factor receptor, 2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide (3 entities in total) |
Functional Keywords | trka inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P04629 |
Total number of polymer chains | 1 |
Total formula weight | 35526.01 |
Authors | Jayasankar, J.,Kurumbail, R.,Skerratt, S.,Brown, D. (deposition date: 2016-04-19, release date: 2017-03-01, Last modification date: 2024-03-06) |
Primary citation | Skerratt, S.E.,Andrews, M.,Bagal, S.K.,Bilsland, J.,Brown, D.,Bungay, P.J.,Cole, S.,Gibson, K.R.,Jones, R.,Morao, I.,Nedderman, A.,Omoto, K.,Robinson, C.,Ryckmans, T.,Skinner, K.,Stupple, P.,Waldron, G. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. J. Med. Chem., 59:10084-10099, 2016 Cited by PubMed: 27766865DOI: 10.1021/acs.jmedchem.6b00850 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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