5J80

Crystal Structure of Apo Hsp90-alpha N-domain L107A mutant

Summary for 5J80

Entry DOI	10.2210/pdb5j80/pdb
Descriptor	Heat shock protein HSP 90-alpha (2 entities in total)
Functional Keywords	apo structure, chaperone, l107a
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P07900
Total number of polymer chains	1
Total formula weight	25285.38
Authors	Amaral, M.,Matias, P. (deposition date: 2016-04-07, release date: 2017-12-06, Last modification date: 2024-01-10)
Primary citation	Amaral, M.,Kokh, D.B.,Bomke, J.,Wegener, A.,Buchstaller, H.P.,Eggenweiler, H.M.,Matias, P.,Sirrenberg, C.,Wade, R.C.,Frech, M. Protein conformational flexibility modulates kinetics and thermodynamics of drug binding. Nat Commun, 8:2276-2276, 2017 Cited by PubMed: 29273709 DOI: 10.1038/s41467-017-02258-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.17 Å)

Structure validation