5J6C

FMN-dependent Nitroreductase (CDR20291_0767) from Clostridium difficile R20291

Summary for 5J6C

• Entry DOI: 10.2210/pdb5j6c/pdb
• Related: 5J62
• Descriptor: Putative reductase, FLAVIN MONONUCLEOTIDE, IMIDAZOLE, ... (4 entities in total)
• Functional Keywords: nitroreductase, hypervirulent, metronidazole resistance, oxidoreductase
• Biological source: Peptoclostridium difficile (strain R20291)
• Total number of polymer chains: 2
• Total formula weight: 47652.40

Authors

Powell, S.M.,Wang, B.,Hessami, N.,Najar, F.Z.,Thomas, L.M.,West, A.H.,Karr, E.A.,Richter-Addo, G.B. (deposition date: 2016-04-04, release date: 2016-09-21, Last modification date: 2023-09-27)

• Primary citation: Wang, B.,Powell, S.M.,Hessami, N.,Najar, F.Z.,Thomas, L.M.,Karr, E.A.,West, A.H.,Richter-Addo, G.B.; Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole.; Nitric Oxide, 60:32-39, 2016; PubMed: 27623089; DOI: 10.1016/j.niox.2016.09.003

Experimental method

X-RAY DIFFRACTION (2.096 Å)