5J41
Glutathione S-transferase bound with hydrolyzed Piperlongumine
Summary for 5J41
Entry DOI | 10.2210/pdb5j41/pdb |
Descriptor | Glutathione S-transferase P, 3-(3,4,5-trimethoxyphenyl)propanoic acid, GLUTATHIONE, ... (5 entities in total) |
Functional Keywords | gstp1, piperlongumine, glutathione, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P09211 |
Total number of polymer chains | 2 |
Total formula weight | 47978.76 |
Authors | Harshbarger, W.,Gondi, S.,Ficarro, S.,Hunter, J.,Udayakumar, D.,Gurbani, D.,Marto, J.,Westover, K. (deposition date: 2016-03-31, release date: 2016-11-30, Last modification date: 2023-09-27) |
Primary citation | Harshbarger, W.,Gondi, S.,Ficarro, S.B.,Hunter, J.,Udayakumar, D.,Gurbani, D.,Singer, W.D.,Liu, Y.,Li, L.,Marto, J.A.,Westover, K.D. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. J. Biol. Chem., 292:112-120, 2017 Cited by PubMed: 27872191DOI: 10.1074/jbc.M116.750299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.19035345576 Å) |
Structure validation
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