5J41

Glutathione S-transferase bound with hydrolyzed Piperlongumine

Summary for 5J41

Entry DOI	10.2210/pdb5j41/pdb
Descriptor	Glutathione S-transferase P, 3-(3,4,5-trimethoxyphenyl)propanoic acid, GLUTATHIONE, ... (5 entities in total)
Functional Keywords	gstp1, piperlongumine, glutathione, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P09211
Total number of polymer chains	2
Total formula weight	47978.76
Authors	Harshbarger, W.,Gondi, S.,Ficarro, S.,Hunter, J.,Udayakumar, D.,Gurbani, D.,Marto, J.,Westover, K. (deposition date: 2016-03-31, release date: 2016-11-30, Last modification date: 2023-09-27)
Primary citation	Harshbarger, W.,Gondi, S.,Ficarro, S.B.,Hunter, J.,Udayakumar, D.,Gurbani, D.,Singer, W.D.,Liu, Y.,Li, L.,Marto, J.A.,Westover, K.D. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. J. Biol. Chem., 292:112-120, 2017 Cited by PubMed: 27872191 DOI: 10.1074/jbc.M116.750299 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.19035345576 Å)

Structure validation