5J2Q
HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site
Summary for 5J2Q
Entry DOI | 10.2210/pdb5j2q/pdb |
Related | 5J2M 5J2N 5J2P |
Descriptor | HIV-1 reverse transcriptase p66 subunit, HIV-1 reverse transcriptase p51 domain, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3'), ... (7 entities in total) |
Functional Keywords | hiv-1, reverse transcriptase, rt, dna, double stranded dna, dsdna, mismatch, efda, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, efda-monophosphate, efda-mp, inhibitors, nrti, tdrti, translocation defective, p site, n site, pre-translocation, post-translocation, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) More |
Total number of polymer chains | 4 |
Total formula weight | 131954.56 |
Authors | Salie, Z.L.,Kirby, K.A.,Sarafianos, S.G. (deposition date: 2016-03-29, release date: 2016-08-03, Last modification date: 2023-09-27) |
Primary citation | Salie, Z.L.,Kirby, K.A.,Michailidis, E.,Marchand, B.,Singh, K.,Rohan, L.C.,Kodama, E.N.,Mitsuya, H.,Parniak, M.A.,Sarafianos, S.G. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). Proc.Natl.Acad.Sci.USA, 113:9274-9279, 2016 Cited by PubMed: 27489345DOI: 10.1073/pnas.1605223113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.789 Å) |
Structure validation
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