5J1E

Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase

Summary for 5J1E

Entry DOI	10.2210/pdb5j1e/pdb
Descriptor	HIV-1 REVERSE TRANSCRIPTASE P66 DOMAIN, HIV-1 REVERSE TRANSCRIPTASE P51 DOMAIN, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More
Total number of polymer chains	4
Total formula weight	228877.28
Authors	Kirby, K.A.,Sarafianos, S.G. (deposition date: 2016-03-29, release date: 2016-06-15, Last modification date: 2023-09-27)
Primary citation	Kankanala, J.,Kirby, K.A.,Liu, F.,Miller, L.,Nagy, E.,Wilson, D.J.,Parniak, M.A.,Sarafianos, S.G.,Wang, Z. Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H. J.Med.Chem., 59:5051-5062, 2016 Cited by PubMed: 27094954 DOI: 10.1021/acs.jmedchem.6b00465 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation