5IV4

Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1

Summary for 5IV4

Entry DOI	10.2210/pdb5iv4/pdb
Descriptor	Adenylate cyclase type 10, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... (9 entities in total)
Functional Keywords	human soluble adenylyl cyclase complex lre1 inhibitor, lyase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : Q96PN6
Total number of polymer chains	1
Total formula weight	55525.07
Authors	Kleinboelting, S.,Steegborn, C. (deposition date: 2016-03-18, release date: 2016-08-17, Last modification date: 2022-11-30)
Primary citation	Ramos-Espiritu, L.,Kleinboelting, S.,Navarrete, F.A.,Alvau, A.,Visconti, P.E.,Valsecchi, F.,Starkov, A.,Manfredi, G.,Buck, H.,Adura, C.,Zippin, J.H.,van den Heuvel, J.,Glickman, J.F.,Steegborn, C.,Levin, L.R.,Buck, J. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12:838-844, 2016 Cited by PubMed: 27547922 DOI: 10.1038/nchembio.2151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation