5IBS

Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2

Summary for 5IBS

• Entry DOI: 10.2210/pdb5ibs/pdb
• Related: 5IBM
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total)
• Functional Keywords: tyrosine phosphatase shp2, tyrosine-protein phosphatase non-receptor type 11, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q06124
• Total number of polymer chains: 2
• Total formula weight: 120668.10

Authors

Blacklow, S.C.,Stams, T.,Fodor, M.,LaRochelle, J.R. (deposition date: 2016-02-22, release date: 2016-04-13, Last modification date: 2023-09-27)

• Primary citation: LaRochelle, J.R.,Fodor, M.,Xu, X.,Durzynska, I.,Fan, L.,Stams, T.,Chan, H.M.,LaMarche, M.J.,Chopra, R.,Wang, P.,Fortin, P.D.,Acker, M.G.,Blacklow, S.C.; Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.; Biochemistry, 55:2269-2277, 2016; PubMed: 27030275; DOI: 10.1021/acs.biochem.5b01287

Experimental method

X-RAY DIFFRACTION (2.32 Å)