5I4N

Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP

Summary for 5I4N

Entry DOI	10.2210/pdb5i4n/pdb
Descriptor	Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	transferase, pseudokinase, atp binding
Biological source	Homo sapiens (Human)
Cellular location	Endomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains	1
Total formula weight	33865.74
Authors	Shiau, A.K.,Motamedi, A. (deposition date: 2016-02-12, release date: 2016-04-13, Last modification date: 2023-09-27)
Primary citation	Leroy, E.,Dusa, A.,Colau, D.,Motamedi, A.,Cahu, X.,Mouton, C.,Huang, L.J.,Shiau, A.K.,Constantinescu, S.N. Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix. Biochem.J., 473:1579-1591, 2016 Cited by PubMed: 27029346 DOI: 10.1042/BCJ20160085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation