5I2E
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound Sulfamate Inhibitor 3a:3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine
Summary for 5I2E
Entry DOI | 10.2210/pdb5i2e/pdb |
Related | 3TW2 4EQE 4EQG 4EQH 5I2F |
Descriptor | Histidine triad nucleotide-binding protein 1, 3-(5-O-{[3-(1H-indol-3-yl)propanoyl]sulfamoyl}-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hint, histidine triad, hit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P49773 |
Total number of polymer chains | 2 |
Total formula weight | 28826.01 |
Authors | Strom, A.M.,Finzel, B.C.,Wagner, C.R. (deposition date: 2016-02-08, release date: 2016-06-22, Last modification date: 2023-09-27) |
Primary citation | Shah, R.,Strom, A.,Zhou, A.,Maize, K.M.,Finzel, B.C.,Wagner, C.R. Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. Acs Med.Chem.Lett., 7:780-784, 2016 Cited by PubMed: 27563403DOI: 10.1021/acsmedchemlett.6b00169 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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