5HZE
Mek1 adopts DFG-out conformation when bound to an analog of E6201.
Summary for 5HZE
Entry DOI | 10.2210/pdb5hze/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, (3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | mek1, e6201, covalent inhibitor, kinase, mek-1, map2k1, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750 |
Total number of polymer chains | 1 |
Total formula weight | 39360.91 |
Authors | |
Primary citation | Larsen, N.A.,Bloudoff, K.,Subramanian, V.,Nomoto, K.,Wang, J. Mek1 adopts DFG-out conformation when bound to an analog of E6201. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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