5HM0

Crystal structure of the first bromodomain of human BRD4 bound to benzoisoxazoloazepine 3

Summary for 5HM0

• Entry DOI: 10.2210/pdb5hm0/pdb
• Descriptor: Bromodomain-containing protein 4, 6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepine (3 entities in total)
• Functional Keywords: bromodomain, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15435.10

Authors

Jayaram, H.,Poy, F.,Setser, J.W.,Bellon, S.F. (deposition date: 2016-01-15, release date: 2016-02-10, Last modification date: 2023-09-27)

• Primary citation: Albrecht, B.K.,Gehling, V.S.,Hewitt, M.C.,Vaswani, R.G.,Cote, A.,Leblanc, Y.,Nasveschuk, C.G.,Bellon, S.,Bergeron, L.,Campbell, R.,Cantone, N.,Cooper, M.R.,Cummings, R.T.,Jayaram, H.,Joshi, S.,Mertz, J.A.,Neiss, A.,Normant, E.,O'Meara, M.,Pardo, E.,Poy, F.,Sandy, P.,Supko, J.,Sims, R.J.,Harmange, J.C.,Taylor, A.M.,Audia, J.E.; Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials.; J.Med.Chem., 59:1330-1339, 2016; PubMed: 26815195; DOI: 10.1021/acs.jmedchem.5b01882

Experimental method

X-RAY DIFFRACTION (1.395 Å)