5HLF
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A 38-MER HAIRPIN TEMPLATE-PRIMER DNA APTAMER AND AN ALPHA-CARBOXYPHOSPHONATE INHIBITOR
Summary for 5HLF
Entry DOI | 10.2210/pdb5hlf/pdb |
Related | 3V4I 4R5P 5D3G 5HP1 |
Related PRD ID | PRD_900003 |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (38-MER), ... (9 entities in total) |
Functional Keywords | dna aptamer, 2-o-methylcytidine, p51, p66, transferase, ncrti, nucleotide competing, inhibitor, transferase-inhibitor-dna complex, transferase/inhibitor/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 6 |
Total formula weight | 257379.49 |
Authors | Das, K.,Arnold, E. (deposition date: 2016-01-15, release date: 2016-02-10, Last modification date: 2023-09-27) |
Primary citation | Mullins, N.D.,Maguire, N.M.,Ford, A.,Das, K.,Arnold, E.,Balzarini, J.,Maguire, A.R. Exploring the role of the alpha-carboxyphosphonate moiety in the HIV-RT activity of alpha-carboxy nucleoside phosphonates. Org.Biomol.Chem., 14:2454-2465, 2016 Cited by PubMed: 26813581DOI: 10.1039/c5ob02507a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
Download full validation report