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3V4I

Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP

Summary for 3V4I
Entry DOI10.2210/pdb3v4i/pdb
Related1RTD 1VRT 2ZD1 3KLE 3KLF 3V6D 3V81
DescriptorHIV-1 Reverse Transcriptase P66 subunit, HIV-1 Reverse Transcriptase P51 subunit, DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... (6 entities in total)
Functional Keywordshiv-1 reverse transcriptase, zidovudine, rt-dna complex, transferase-dna complex, drug resistance mutation, aids, dna recombination, dna-directed dna polymerase, rnase h, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotidyltransferase, rna-directed dna polymerase transferase, transferase-dna complex complex, transferase/dna
Biological sourceHuman immunodeficiency virus type 1 BH10 (HIV-1)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains8
Total formula weight259000.16
Authors
Das, K.,Martinez, S.E.,Arnold, E. (deposition date: 2011-12-15, release date: 2012-01-18, Last modification date: 2023-09-13)
Primary citationDas, K.,Martinez, S.E.,Bauman, J.D.,Arnold, E.
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.
Nat.Struct.Mol.Biol., 19:253-259, 2012
Cited by
PubMed: 22266819
DOI: 10.1038/nsmb.2223
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7983 Å)
Structure validation

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