5HI7

Co-crystal structure of human SMYD3 with an aza-SAH compound

Summary for 5HI7

Entry DOI	10.2210/pdb5hi7/pdb
Descriptor	Histone-lysine N-methyltransferase SMYD3, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	smyd3, methyltransferase, oncology, inhibitor, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9H7B4
Total number of polymer chains	1
Total formula weight	50318.00
Authors	Elkins, P.A.,Bonnette, W.G. (deposition date: 2016-01-11, release date: 2016-03-30, Last modification date: 2024-03-06)
Primary citation	Van Aller, G.S.,Graves, A.P.,Elkins, P.A.,Bonnette, W.G.,McDevitt, P.J.,Zappacosta, F.,Annan, R.S.,Dean, T.W.,Su, D.S.,Carpenter, C.L.,Mohammad, H.P.,Kruger, R.G. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure, 24:774-781, 2016 Cited by PubMed: 27066749 DOI: 10.1016/j.str.2016.03.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation