5HEZ
JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209
Summary for 5HEZ
Entry DOI | 10.2210/pdb5hez/pdb |
Related | 4JI9 |
Descriptor | Tyrosine-protein kinase JAK2, CHLORIDE ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | protein kinase, inhibitor, mutation, tyk2, surrogate, p1104a, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 4 |
Total formula weight | 146155.39 |
Authors | Ultsch, M.,Eigenbrot, C. (deposition date: 2016-01-06, release date: 2016-11-09, Last modification date: 2023-11-15) |
Primary citation | Dendrou, C.A.,Cortes, A.,Shipman, L.,Evans, H.G.,Attfield, K.E.,Jostins, L.,Barber, T.,Kaur, G.,Kuttikkatte, S.B.,Leach, O.A.,Desel, C.,Faergeman, S.L.,Cheeseman, J.,Neville, M.J.,Sawcer, S.,Compston, A.,Johnson, A.R.,Everett, C.,Bell, J.I.,Karpe, F.,Ultsch, M.,Eigenbrot, C.,McVean, G.,Fugger, L. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med, 8:363ra149-363ra149, 2016 Cited by PubMed: 27807284DOI: 10.1126/scitranslmed.aag1974 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.66 Å) |
Structure validation
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