5HCV
Identification of Spirooxindole and Dibenzoxazepine Motifs as Potent Mineralocorticoid Receptor Antagonists
Summary for 5HCV
Entry DOI | 10.2210/pdb5hcv/pdb |
Descriptor | Mineralocorticoid receptor, 6-[(~{E})-(3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene)methyl]-4~{H}-1,4-benzoxazin-3-one, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | mineralocorticoid receptor, ligand-binding domain, mr-lbd, antagonists, co-crystal, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 3 |
Total formula weight | 90776.36 |
Authors | Chen, G.,McKeever, B.M. (deposition date: 2016-01-04, release date: 2016-03-09, Last modification date: 2023-09-27) |
Primary citation | Lotesta, S.D.,Marcus, A.P.,Zheng, Y.,Leftheris, K.,Noto, P.B.,Meng, S.,Kandpal, G.,Chen, G.,Zhou, J.,McKeever, B.,Bukhtiyarov, Y.,Zhao, Y.,Lala, D.S.,Singh, S.B.,McGeehan, G.M. Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists. Bioorg.Med.Chem., 24:1384-1391, 2016 Cited by PubMed: 26897089DOI: 10.1016/j.bmc.2016.02.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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