5HA7

Human Aldose Reductase in Complex with NADP+ and WY14643 in Space Group P212121

Summary for 5HA7

• Entry DOI: 10.2210/pdb5ha7/pdb
• Related: 3Q65
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, ... (5 entities in total)
• Functional Keywords: alpha/beta barrel, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 2
• Total formula weight: 74699.59

Authors

Sawaya, M.R.,Cascio, D.,Balendiran, G.K. (deposition date: 2015-12-30, release date: 2016-09-28, Last modification date: 2023-09-27)

• Primary citation: Sawaya, M.R.,Verma, M.,Balendiran, V.,Rath, N.P.,Cascio, D.,Balendiran, G.K.; Characterization of WY 14,643 and its Complex with Aldose Reductase.; Sci Rep, 6:34394-34394, 2016; PubMed: 27721416; DOI: 10.1038/srep34394

Experimental method

X-RAY DIFFRACTION (1.65 Å)