5GSA
EED in complex with an allosteric PRC2 inhibitor
Summary for 5GSA
Entry DOI | 10.2210/pdb5gsa/pdb |
Descriptor | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... (4 entities in total) |
Functional Keywords | eed, prc2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: O75530 Q15910 |
Total number of polymer chains | 4 |
Total formula weight | 92695.62 |
Authors | |
Primary citation | Qi, W.,Zhao, K.,Gu, J.,Huang, Y.,Wang, Y.,Zhang, H.,Zhang, M.,Zhang, J.,Yu, Z.,Li, L.,Teng, L.,Chuai, S.,Zhang, C.,Zhao, M.,Chan, H.,Chen, Z.,Fang, D.,Fei, Q.,Feng, L.,Feng, L.,Gao, Y.,Ge, H.,Ge, X.,Li, G.,Lingel, A.,Lin, Y.,Liu, Y.,Luo, F.,Shi, M.,Wang, L.,Wang, Z.,Yu, Y.,Zeng, J.,Zeng, C.,Zhang, L.,Zhang, Q.,Zhou, S.,Oyang, C.,Atadja, P.,Li, E. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol., 13:381-388, 2017 Cited by PubMed: 28135235DOI: 10.1038/nchembio.2304 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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