5GS4

Crystal structure of estrogen receptor alpha in complex with a stabilized peptide antagonist

Summary for 5GS4

• Entry DOI: 10.2210/pdb5gs4/pdb
• Descriptor: Estrogen receptor, ARG-IAS-ILE-LEU-DNP-ARG-LEU-LEU-GLN, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: estrogen receptor alpha, stabilized peptide, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 29327.37

Authors

Xie, M.,Wang, T.,Li, Z.-G. (deposition date: 2016-08-13, release date: 2017-08-30, Last modification date: 2018-07-18)

• Primary citation: Xie, M.,Zhao, H.,Liu, Q.,Zhu, Y.,Yin, F.,Liang, Y.,Jiang, Y.,Wang, D.,Hu, K.,Qin, X.,Wang, Z.,Wu, Y.,Xu, N.,Ye, X.,Wang, T.,Li, Z.; Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides; J. Med. Chem., 60:8731-8740, 2017; PubMed: 29045135; DOI: 10.1021/acs.jmedchem.7b00732

Experimental method

X-RAY DIFFRACTION (2.4 Å)