5GPG

Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR

Summary for 5GPG

Entry DOI	10.2210/pdb5gpg/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase FKBP3, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... (4 entities in total)
Functional Keywords	complex, kinase, isomerase-transferase complex, isomerase/transferase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: Q00688 Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P42345
Total number of polymer chains	2
Total formula weight	25314.00
Authors	Lee, H.B.,Lee, S.Y.,Rhee, H.W.,Lee, C.W. (deposition date: 2016-08-02, release date: 2016-10-12, Last modification date: 2023-11-08)
Primary citation	Lee, S.Y.,Lee, H.,Lee, H.K.,Lee, S.W.,Ha, S.C.,Kwon, T.,Seo, J.K.,Lee, C.,Rhee, H.W. Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells Acs Cent.Sci., 2:506-516, 2016 Cited by PubMed: 27610411 DOI: 10.1021/acscentsci.6b00137 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation