5GN9
Crystal structure of alternative oxidase from Trypanosoma brucei brucei complexed with cumarin derivative-17b
Summary for 5GN9
Entry DOI | 10.2210/pdb5gn9/pdb |
Related | 5GN5 5GN6 5GN7 |
Descriptor | Alternative oxidase, mitochondrial, FE (III) ION, 4-butyl-7,8-bis(oxidanyl)chromen-2-one (3 entities in total) |
Functional Keywords | alternative oxidase, inhibitor, drug, african trypanosomes, transferase, oxidoreductase |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 4 |
Total formula weight | 151956.91 |
Authors | Balogun, E.O.,Inaoka, D.K.,Shiba, T.,Tsuge, T.,May, B.,Sato, T.,Kido, Y.,Takeshi, N.,Aoki, T.,Honma, T.,Tanaka, A.,Inoue, M.,Matsuoka, S.,Michels, P.A.M.,Watanabe, Y.,Moore, A.L.,Harada, S.,Kita, K. (deposition date: 2016-07-19, release date: 2017-07-26, Last modification date: 2023-11-08) |
Primary citation | Balogun, E.O.,Inaoka, D.K.,Shiba, T.,Tsuge, C.,May, B.,Sato, T.,Kido, Y.,Nara, T.,Aoki, T.,Honma, T.,Tanaka, A.,Inoue, M.,Matsuoka, S.,Michels, P.A.M.,Watanabe, Y.I.,Moore, A.L.,Harada, S.,Kita, K. Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase ofTrypanosoma brucei brucei. Faseb J., 33:13002-13013, 2019 Cited by PubMed: 31525300DOI: 10.1096/fj.201901342R PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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