5G5W

Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal Glucocorticoid receptor modulators

Summary for 5G5W

Entry DOI	10.2210/pdb5g5w/pdb
Descriptor	GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	hormone, glucocorticoid receptor, nuclear hormone receptor, steroid receptor, signaling protein, ligand complex, peptide complex
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	34415.56
Authors	Hemmerling, M.,Edman, K.,Lepisto, M.,Eriksson, A.,Ivanova, S.,Dahmen, J.,Rehwinkel, H.,Berger, M.,Hendrickx, R.,Dearman, M.,Jellesmark-Jensen, T.,Wissler, L.,Hansson, T. (deposition date: 2016-06-08, release date: 2017-02-15, Last modification date: 2024-01-10)
Primary citation	Hemmerling, M.,Edman, K.,Lepisto, M.,Eriksson, A.,Ivanova, S.,Dahmen, J.,Rehwinkel, H.,Berger, M.,Hendrickx, R.,Dearman, M.,Jensen, T.J.,Wissler, L.,Hansson, T. Discovery of Indazole Ethers as Novel, Potent, Non-Steroidal Glucocorticoid Receptor Modulators. Bioorg.Med.Chem.Lett., 26:5741-, 2017 Cited by PubMed: 27810243 DOI: 10.1016/J.BMCL.2016.10.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation