5FTO
Crystal structure of the ALK kinase domain in complex with Entrectinib
Summary for 5FTO
Entry DOI | 10.2210/pdb5fto/pdb |
Related | 5FTQ |
Descriptor | ALK TYROSINE KINASE RECEPTOR, Entrectinib (3 entities in total) |
Functional Keywords | transferase, kinase inhibitors, cancer, drug discovery, alk, trk, ros1, anaplastic large cell lymphoma (alcl), non small cell large cancer (nsclc), neuroblastoma, colorectal cancer (crc) |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 35895.25 |
Authors | Bossi, R.,Canevari, G.,Fasolini, M.,Menichincheri, M.,Ardini, E.,Magnaghi, P.,Avanzi, N.,Banfi, P.,Buffa, L.,Ceriani, L.,Colombo, M.,Corti, L.,Donati, D.,Felder, E.,Fiorelli, C.,Fiorentini, F.,Galvani, A.,Isacchi, A.,Lombardi Borgia, A.,Marchionni, C.,Nesi, M.,Orrenius, C.,Panzeri, A.,Perrone, E.,Pesenti, E.,Rusconi, L.,Saccardo, M.B.,Vanotti, E.,Orsini, P. (deposition date: 2016-01-14, release date: 2016-04-06, Last modification date: 2024-01-10) |
Primary citation | Menichincheri, M.,Ardini, E.,Magnaghi, P.,Avanzi, N.,Banfi, P.,Bossi, R.T.,Buffa, L.,Canevari, G.,Ceriani, L.,Colombo, M.,Corti, L.,Donati, D.,Fasolini, M.,Felder, E.R.,Fiorelli, C.,Fiorentini, F.,Galvani, A.,Isacchi, A.,Borgia, A.L.,Marchionni, C.,Nesi, M.,Orrenius, C.,Panzeri, A.,Pesenti, E.,Rusconi, L.,Saccardo, B.M.,Vanotti, E.,Perrone, E.,Orsini, P. Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (Alk), C-Ros Oncogene 1 Kinase (Ros1), and Pan-Tropomyosin Receptor Kinases (Pan-Trks) Inhibitor. J.Med.Chem., 59:3392-, 2016 Cited by PubMed: 27003761DOI: 10.1021/ACS.JMEDCHEM.6B00064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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