5FQS
Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 3.
Summary for 5FQS
Entry DOI | 10.2210/pdb5fqs/pdb |
Related | 5FQP 5FQR 5FQT 5FQV |
Descriptor | ESTROGEN RECEPTOR, (E)-3-[4-(6-HYDROXY-2-ISOBUTYL-1-METHYL-3,4-DIHYDROISOQUINOLIN-1-YL)PHENYL]PROP-2-ENOIC ACID (3 entities in total) |
Functional Keywords | signaling protein, breast cancer, estrogen receptor downregulator, fulvestrant, thiq, nuclear hormone receptor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 |
Total number of polymer chains | 1 |
Total formula weight | 28623.58 |
Authors | Scott, J.S.,Bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. (deposition date: 2015-12-14, release date: 2016-02-10, Last modification date: 2024-05-08) |
Primary citation | Scott, J.S.,Bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7:94-, 2016 Cited by PubMed: 26819673DOI: 10.1021/ACSMEDCHEMLETT.5B00413 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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